Jun Sasaki, MD
Associate Cardiologist, Department of Cardiology
Assistant Professor, Harvard Medical School
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Jun Sasaki, MD
Associate Cardiologist, Department of Cardiology
Assistant Professor, Harvard Medical School
Medical Services
Languages
English
Japanese
Education
Medical School
Tokyo Medical and Dental University
2005
Bunkyo, Tokyo
Japan
Residency
Pediatrics
Elmhurst Hospital Center/Mount Sinai
2010
Queens
NY
Fellowship
Pediatric Critical Care Medicine
Nicklaus Children's Hospital
2013
Miami
FL
Fellowship
Cardiac Critical Care
Nicklaus Children's Hospital
2014
Miami
FL
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Critical Care Medicine)
Professional History
Dr. Sasaki received his medical degree from Tokyo Medical and Dental University in Japan and completed his pediatric residency and chief residency at Elmhurst Hospital Center/Mount Sinai in NY, followed by a pediatric critical care medicine fellowship and an additional year of training in cardiac critical care at Nicklaus Children's Hospital in FL. He is board certified in pediatrics and pediatric critical care medicine.
Approach to Care
I keep my passion for taking care of sick children and their families. With a multidisciplinary team approach, we make sure our cardiac intensive care unit at Boston Children's Hospital is a safe place for them to recover.
Publications
Hydrogen Molecule Delivery System to Ischemic Intestine Using Resuscitative Endovascular Balloon Occlusion of Aorta in Hemorrhagic Shock-A Proof-of-Concept Study. View Abstract
Impact of prophylactic drain placement on intra-abdominal infections after gastrectomy: nationwide inpatient database study in Japan. View Abstract
Patient characteristics of medical encounters at the Olympic Stadium during the Tokyo 2020 Olympic and Paralympic games. View Abstract
Gentamicin-Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections. View Abstract
Predictive Factors of Prolonged Mechanical Ventilation After Complete Atrioventricular Septal Defect Surgery. View Abstract
Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in mice. View Abstract
Japanese Society for Burn Injuries Burn Registry 2011: 10-year Analysis Report. View Abstract
Blood glucose upon return of spontaneous circulation and neurological outcomes following out-of-hospital cardiac arrest. View Abstract
Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial. View Abstract
The modified Japanese Association for Acute Medicine disseminated intravascular coagulation diagnostic criteria in sepsis is useful for an indicator of initiating treatment for disseminated intravascular coagulation. View Abstract
Optimizing resuscitative endovascular balloon occlusion of the aorta outcomes using phenotype analysis: A nationwide study. View Abstract
Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial. View Abstract
Adjunctive Corticosteroids for Hypotension in the Pediatric Cardiac ICU: Single-Center Retrospective Study, 2020-2021. View Abstract
A web questionnaire-based survey on post-COVID-19 condition for infectious disease specialists in Japan. View Abstract
Additional biomarkers and emm types associated with group A streptococcal toxic shock syndrome: a Japanese nationwide observational study. View Abstract
Functional outcomes following injury in centenarians: a nationwide retrospective observational study. View Abstract
Carbapenem Usage in the Initial Antibiotic Therapy of Sepsis in Japanese Intensive Care Units. View Abstract
Pediatric Blunt Liver and Spleen Injury Treated in Hospitals With Pediatric Intensive Care Units: Post-hoc Analysis of a Multicenter, Retrospective Observational Study. View Abstract
Pediatric burn injury at home over 30 years: A road to future prevention. View Abstract
Simple severity scale for perforated peptic ulcer with generalized peritonitis: a derivation and internal validation study. View Abstract
Prehospital endotracheal intubation for traumatic out-of-hospital cardiac arrest and improved neurological outcomes. View Abstract
Sustained Performance of Cardiac Arrest Prevention in Pediatric Cardiac Intensive Care Units. View Abstract
Multiple site inflammation and acute kidney injury in crush syndrome. View Abstract
Urine Output and Development of Acute Kidney Injury in Sepsis: A Multicenter Observational Study. View Abstract
Novel weaning assessment for veno-arteriovenous to veno-venous extracorporeal membrane oxygenation using pump-controlled retrograde trial off. View Abstract
Follow-up computed tomography and unexpected hemostasis in non-operative management of pediatric blunt liver and spleen injury. View Abstract
Immediate Angiography and Decreased In-Hospital Mortality of Adult Trauma Patients: A Nationwide Study. View Abstract
Hyperoxia for sepsis and development of acute lung injury with increased mortality. View Abstract
Optimal tentative abdominal closure for open abdomen: a multicenter retrospective observational study (OPTITAC study). View Abstract
Influence of the coronavirus infectious disease 2019 pandemic on infectious disease practice and infection control in Japan: A web questionnaire survey. View Abstract
Early restricted oxygen therapy after resuscitation from cardiac arrest (ER-OXYTRAC): protocol for a stepped-wedge cluster randomised controlled trial. View Abstract
Cushing Index Based on Cushing Signs to Predict In-Hospital Death and Early Intervention for Minor Head Injury. View Abstract
Healthcare costs for hospitalized COVID-19 patients in a Japanese university hospital: a cross-sectional study. View Abstract
Intercellular crosstalk in adult dental pulp is mediated by heparin-binding growth factors Pleiotrophin and Midkine. View Abstract
Early symptoms preceding post-infectious irritable bowel syndrome following COVID-19: a retrospective observational study incorporating daily gastrointestinal symptoms. View Abstract
Frailty and Neurologic Outcomes of Patients Resuscitated From Nontraumatic Out-of-Hospital Cardiac Arrest: A Prospective Observational Study. View Abstract
Safety of bloodless open-heart surgery on cardiopulmonary bypass in selected children: A single center experience with minimal invasive extracorporeal circulation. View Abstract
Preventing Cardiac Arrest in the Pediatric Cardiac Intensive Care Unit Through Multicenter Collaboration. View Abstract
Characteristics of Laparoscopic Surgery for Trauma Patients and Risks of Conversion to Open Laparotomy. View Abstract
Contemporary risk factors for a longer hospital stay following bidirectional cavopulmonary anastomosis. View Abstract
Effects of tranexamic acid on coagulofibrinolytic markers during the early stage of severe trauma: A propensity score-matched analysis. View Abstract
D-dimer for screening of aortic dissection in patients with ST-elevation myocardial infarction. View Abstract
The Epidemiology and Outcome of Pericardial Effusion in Hospitalized Children: A National Database Analysis. View Abstract
Impact of COVID-19 pandemic on the care of severe burns in Japan: Repeated survey of specialized burn care facilities. View Abstract
Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis. View Abstract
A Case-Crossover Analysis of the Association between Exposure to Total PM2.5 and Its Chemical Components and Emergency Ambulance Dispatches in Tokyo. View Abstract
Early intubation and decreased in-hospital mortality in patients with coronavirus disease 2019. View Abstract
Real-world economic evaluation of prospective rapid whole-genome sequencing compared to a matched retrospective cohort of critically ill pediatric patients in the United States. View Abstract
Survey on the current status of the indication and implementation protocols for bile replacement in patients with external biliary drainage with special reference to infection control. View Abstract
Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan. View Abstract
Critical Care Unit Organizational and Personnel Factors Impact Cardiac Arrest Prevention and Rescue in the Pediatric Cardiac Population. View Abstract
Outcomes of Catheter-Related Arterial and Venous Thrombosis After Enoxaparin Therapy in Neonates and Infants With Congenital Heart Disease. View Abstract
Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats. View Abstract
Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis. View Abstract
Emergency angiography for trauma patients and potential association with acute kidney injury. View Abstract
Epidemiology of Neonatal Acute Kidney Injury After Cardiac Surgery Without Cardiopulmonary Bypass. View Abstract
Epidemiology of Acute Kidney Injury After Neonatal Cardiac Surgery: A Report From the Multicenter Neonatal and Pediatric Heart and Renal Outcomes Network. View Abstract
Incidence and Impact of Dysglycemia in Patients with Sepsis Under Moderate Glycemic Control. View Abstract
Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU. View Abstract
Association of frailty on treatment outcomes among patients with suspected infection treated at emergency departments. View Abstract
Quick sequential organ failure assessment score combined with other sepsis-related risk factors to predict in-hospital mortality: Post-hoc analysis of prospective multicenter study data. View Abstract
Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells. View Abstract
Antithrombotic drugs have a minimal effect on intraoperative blood loss during emergency surgery for generalized peritonitis: a nationwide retrospective cohort study in Japan. View Abstract
Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients. View Abstract
The interplay between bystander cardiopulmonary resuscitation and ambient temperature on neurological outcome after cardiac arrest: A nationwide observational cohort study. View Abstract
Hyperoxemia during resuscitation of trauma patients and increased intensive care unit length of stay: inverse probability of treatment weighting analysis. View Abstract
Accuracy for Mortality Prediction With Additive Biomarkers Including Interleukin-6 in Critically Ill Patients: A Multicenter Prospective Observational Study. View Abstract
The Japanese Medical Science Federation COVID-19 Expert Opinion English Version. View Abstract
COVID-19 shares clinical features with anti-melanoma differentiation-associated protein 5 positive dermatomyositis and adult Still's disease. View Abstract
Quick sequential organ failure assessment versus systemic inflammatory response syndrome criteria for emergency department patients with suspected infection. View Abstract
Predictors of severe sepsis-related in-hospital mortality based on a multicenter cohort study: The Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis, and Trauma study. View Abstract
Chromosomal microarray detects genetic risks of neurodevelopmental disorders in newborns with congenital heart disease. View Abstract
Medicine at mass gatherings: current progress of preparedness of emergency medical services and disaster medical response during 2020 Tokyo Olympic and Paralympic Games from the perspective of the Academic Consortium (AC2020). View Abstract
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts. View Abstract
The provisional extension to induce complete attachment technique is associated with abdominal aortic remodeling and reduces aorta-related adverse events after aortic dissection. View Abstract
Dermal fibroblast-like cells reprogrammed directly from adipocytes in mouse. View Abstract
Including Disparity in a Congenital Heart Surgery Regionalization Model. View Abstract
Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension. View Abstract
Characteristics and outcomes of frail patients with suspected infection in intensive care units: a descriptive analysis from a multicenter cohort study. View Abstract
Current spectrum of causative pathogens in sepsis: A prospective nationwide cohort study in Japan. View Abstract
Identifying Septic Shock Populations Benefitting From Polymyxin B Hemoperfusion: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model. View Abstract
A Case of UDP-Galactose 4'-Epimerase Deficiency Associated with Dyshematopoiesis and Atrioventricular Valve Malformations: An Exceptional Clinical Phenotype Explained by Altered N-Glycosylation with Relative Preservation of the Leloir Pathway. View Abstract
Comparison of prognostic models for burn patients: A retrospective nationwide registry study. View Abstract
Checklist for infection control in the emergency department. View Abstract
Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model. View Abstract
Central Venous Catheter Utilization and Complications in the Pediatric Cardiac ICU: A Report From the Pediatric Cardiac Critical Care Consortium (PC4). View Abstract
Safety of Interhospital ECMO Transport by Low-Volume ECMO Transport Centers. View Abstract
Delays in Surgical Intervention and Temporary Hemostasis Using Resuscitative Endovascular Balloon Occlusion of the aorta (REBOA): Influence of Time to Operating Room on Mortality. View Abstract
Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU). View Abstract
Significance of body temperature in elderly patients with sepsis. View Abstract
Clinical characteristics of patients with severe sepsis and septic shock in relation to bacterial virulence of beta-hemolytic Streptococcus and Streptococcus pneumoniae. View Abstract
The SIRS criteria have better performance for predicting infection than qSOFA scores in the emergency department. View Abstract
Demographics, Treatments, and Outcomes of Acute Respiratory Distress Syndrome: the Focused Outcomes Research in Emergency Care in Acute Respiratory Distress Syndrome, Sepsis, and Trauma (FORECAST) Study. View Abstract
The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome. View Abstract
Early outcome prediction with quantitative pupillary response parameters after out-of-hospital cardiac arrest: A multicenter prospective observational study?. View Abstract
Impact of blood glucose abnormalities on outcomes and disease severity in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis. View Abstract
History of diabetes may delay antibiotic administration in patients with severe sepsis presenting to emergency departments. View Abstract
Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis. View Abstract
Endoscopic removal of foreign bodies: A retrospective study in Japan. View Abstract
Risk modifiers of acute respiratory distress syndrome in patients with non-pulmonary sepsis: a retrospective analysis of the FORECAST study. View Abstract
Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study. View Abstract
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is associated with improved survival in severely injured patients: A propensity score matching analysis. View Abstract
Epinephrine during resuscitation of traumatic cardiac arrest and increased mortality: a post hoc analysis of prospective observational study. View Abstract
Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model. View Abstract
Trends in sepsis care in Japan: comparison of two sepsis cohort studies conducted by the Japanese Association for Acute Medicine. View Abstract
Prognostic Accuracy of Quick SOFA is different according to the severity of illness in infectious patients. View Abstract
In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission. View Abstract
Variations in infection sites and mortality rates among patients in intensive care units with severe sepsis and septic shock in Japan. View Abstract
Impact of Body Temperature Abnormalities on the Implementation of Sepsis Bundles and Outcomes in Patients With Severe Sepsis: A Retrospective Sub-Analysis of the Focused Outcome Research on Emergency Care for Acute Respiratory Distress Syndrome, Sepsis and Trauma Study. View Abstract
Role of disseminated intravascular coagulation in severe sepsis. View Abstract
Nighttime and non-business days are not associated with increased risk of in-hospital mortality in patients with severe sepsis in intensive care units in Japan: The JAAM FORECAST study. View Abstract
Artificial intelligence to predict needs for urgent revascularization from 12-leads electrocardiography in emergency patients. View Abstract
Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study. View Abstract
Renal Function and Outcome of Out-of-Hospital Cardiac Arrest - Multicenter Prospective Study (SOS-KANTO 2012 Study). View Abstract
A survey on infection control in emergency departments in Japan. View Abstract
Quantitative assessment of pupillary light reflex for early prediction of outcomes after out-of-hospital cardiac arrest: A multicentre prospective observational study. View Abstract
Impact of cardiopulmonary resuscitation time on the effectiveness of emergency department thoracotomy after blunt trauma. View Abstract
A novel early risk assessment tool for detecting clinical outcomes in patients with heat-related illness (J-ERATO score): Development and validation in independent cohorts in Japan. View Abstract
Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury. View Abstract
Hydrogen gas inhalation inhibits progression to the "irreversible" stage of shock after severe hemorrhage in rats. View Abstract
Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study. View Abstract
The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans. View Abstract
Fibrinogen level on admission is a predictor for massive transfusion in patients with severe blunt trauma: Analyses of a retrospective multicentre observational study. View Abstract
Generation of kidney tubular organoids from human pluripotent stem cells. View Abstract
Development of Novel Criteria of the "Lethal Triad" as an Indicator of Decision Making in Current Trauma Care: A Retrospective Multicenter Observational Study in Japan. View Abstract
Can Early Aggressive Administration of Fresh Frozen Plasma Improve Outcomes in Patients with Severe Blunt Trauma?--A Report by the Japanese Association for the Surgery of Trauma. View Abstract
HIGH D-DIMER LEVELS PREDICT A POOR OUTCOME IN PATIENTS WITH SEVERE TRAUMA, EVEN WITH HIGH FIBRINOGEN LEVELS ON ARRIVAL: A MULTICENTER RETROSPECTIVE STUDY. View Abstract
Prognostic factors of Streptococcus pneumoniae infection in adults. View Abstract
Pharmacokinetics and skin-tissue penetration of daptomycin in rats. View Abstract
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