Patricia Ellen Grant, MD
Director of the Fetal Neonatal Neuroimaging and Developmental Science Center (FNNDSC); Director of Faculty Affairs, Department of Radiology; Director of Research, Fetal Care and Surgery Center; Neuroradiologist, Department of Radiology
Käthe Beutler, MD Harvard Professor of Pediatrics; Professor of Radiology, Harvard Medical School
Image
Patricia Ellen Grant, MD
Director of the Fetal Neonatal Neuroimaging and Developmental Science Center (FNNDSC); Director of Faculty Affairs, Department of Radiology; Director of Research, Fetal Care and Surgery Center; Neuroradiologist, Department of Radiology
Käthe Beutler, MD Harvard Professor of Pediatrics; Professor of Radiology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
BSc, Physics
University of Toronto
1984
Toronto, Ontario
Canada
Graduate School
MSc, Theoretical Physics
University of Toronto
1988
Toronto, Ontario
Canada
Medical School
University of Toronto
1989
Toronto, Ontario
Canada
Internship
St. Paul's Hospital
1990
Vancouver, British Columbia
Canada
Residency
Radiology
Vancouver General Hospital
1994
Vancouver, British Columbia
Canada
Fellowship
Neuroradiology; Pediatric Neuroradiology
University of California, San Francisco
1996
San Francisco
CA
Certifications
American Board of Radiology (Diagnostic Radiology)
American Board of Radiology (Neuroradiology)
Professional History
Dr. Grant is the Käthe Beutler, MD Harvard Professor of Pediatrics and Professor of Radiology at Harvard Medical School. She is the founding Director of the Fetal Neonatal Neuroimaging and Developmental Science Center (FNNDSC) in the Departments of Medicine and Radiology, the Director of Faculty Affairs in the Department of Radiology, the Direct of Research for the Division of Maternal-Fetal Medicine and Surgery and a clinical neuroradiologist at Boston Children’s Hospital.
Dr. Grant founded the FNNDSC in 2009 to develop and optimize tools and analysis streams to better detect and understand both normal and abnormal brain physiology and development. The primary goal is to provide phenotypic and mechanistic information that enables optimization of cognitive, behavioral, and neurological outcomes in children with a focus on fetuses, neonates, infants, and toddlers. Three modalities are being developed in the FNNDSC: Magnetic Resonance Imaging (MRI), Magnetoencephalography (MEG) and quantitative Near Infrared Spectroscopy (qNIRS). She leads a team of MR physicists and engineers doing pulse sequence development and novel MRI analysis at the forefront of fetal and placental MRI. Her team build a novel pediatric specific MEG system that is now FDA approved and provides clinical services for presurgical evaluation of infants and toddlers with epilepsy.
She is a pioneer of frequency domain NIRS (FDNIRS) and diffuse correlation spectroscopy (DCS) which provides quantitative bedside measures of cerebral blood flow and oxygen consumption. To support the computational needs of complex data analysis, her team has developed a sophisticated computational infrastructure in collaboration with RedHat to support deep-learning approaches on large datasets and real time data analysis.
The FNNDSC currently has over 60 members with 17 faculty and 6 postdoctoral students. Dr. Grant is a Senior Fellow of the International Society of Magnetic Resonance in Medicine (ISMRM) and sits on the Board of Scientific Counselors for National Institute of Child Health and Human Development. In 2021 she received the Outstanding Contributions in Research Award from the American Society of Neuroradiology and in 2022 she received the Gold Medal Award from the American Society of Pediatric Neuroradiology. She is currently PI/MPI of 6 NIH grants and her center has over $40M of active funding.
Approach to Care
As a clinical neuroradiologist, I work behind the scenes. I rarely meet the children and their families in person but I am always thinking about the individual child and the family behind the images. What knowledge can our images provide to best guide care for that individual child?
I started out as a physicist studying very theoretical concepts but switched into medicine to have a more direct human impact. I chose imaging as a specialty because I enjoy leveraging technology to provide the most relevant information possible. My research also focuses on developing and optimizing technological innovations to improve our ability to diagnose and manage pediatric disorders.
I started out as a physicist studying very theoretical concepts but switched into medicine to have a more direct human impact. I chose imaging as a specialty because I enjoy leveraging technology to provide the most relevant information possible. My research also focuses on developing and optimizing technological innovations to improve our ability to diagnose and manage pediatric disorders.
Publications
Machine learning to infer neurocognitive testing scores among adolescents and young adults with congenital heart disease. View Abstract
Insights into Temporal and Spatial Dynamics of Short Association Fiber Formation in the Human Fetal Brain. View Abstract
Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI. View Abstract
Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities. View Abstract
Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia. View Abstract
Maternal Childhood Neglect is Linked to Greater Infant Cortisol Levels and Larger Infant Limbic Volumes. View Abstract
Conditional deep generative normative modeling for structural and developmental anomaly detection in the fetal brain. View Abstract
The Role of Scalp EEG Recordings During Cortical Visual Prosthesis Testing. View Abstract
Design and rationale of "Antecedents and correlates of well-being in young adults with congenital heart disease in the Boston Circulatory Arrest Study (BCAS-adult)". View Abstract
Fetal MRI: Radiofrequency Safety Assessment at 3 Tesla. View Abstract
Bahir Dar Child Development Cross-Sectional Study, Ethiopia: study protocol. View Abstract
Towards automatic US-MR fetal brain image registration with learning-based methods. View Abstract
Graph-based prototype inverse-projection for identifying cortical sulcal pattern abnormalities in congenital heart disease. View Abstract
Magnetic resonance imaging findings in SCN1A-related epilepsies and Dravet syndrome: A systematic review. View Abstract
Management and Outcomes in Isolated Congenital Aqueductal Stenosis: A Single-Center Retrospective Cohort Study. View Abstract
Impact of maternal antenatal nutrition and infection treatment interventions on Longitudinal Infant Development and Growth in rural Ethiopia: protocol of the LIDG child follow-up study. View Abstract
Symptoms Do Not Predict White Matter Injury in the Watershed Regions in Children with Moyamoya. View Abstract
Proceedings of the 15th International Newborn Brain Conference: Neuro-imaging studies: Fota Island, Cork, Ireland, February 28th - March 2nd 2024. View Abstract
Whole-body hypothermia in mild neonatal encephalopathy: protocol for a multicentre phase III randomised controlled trial. View Abstract
Network conditioning for synergistic learning on partial annotations. View Abstract
Magnetoencephalography for the pediatric population, indications, acquisition and interpretation for the clinician. View Abstract
Meta-regression of sulcal patterns, clinical and environmental factors on neurodevelopmental outcomes in participants with multiple CHD types. View Abstract
Automatic cortical surface parcellation in the fetal brain using attention-gated spherical U-net. View Abstract
Publisher Correction to: Morphological Features of Language Regions in Individuals with Tuberous Sclerosis Complex. View Abstract
A Prospective Multi-Institutional Study Comparing the Brain Development in the Third Trimester between Opioid-Exposed and Nonexposed Fetuses Using Advanced Fetal MR Imaging Techniques. View Abstract
Divergent growth of the transient brain compartments in fetuses with nonsyndromic isolated clefts involving the primary and secondary palate. View Abstract
Zero-DeepSub: Zero-shot deep subspace reconstruction for rapid multiparametric quantitative MRI using 3D-QALAS. View Abstract
Association between placental oxygen transport and fetal brain cortical development: a study in monochorionic diamniotic twins. View Abstract
Deep Learning-Based Visual Complexity Analysis of Electroencephalography Time-Frequency Images: Can It Localize the Epileptogenic Zone in the Brain? View Abstract
Shape-aware Segmentation of the Placenta in BOLD Fetal MRI Time Series. View Abstract
Association of genetic and sulcal traits with executive function in congenital heart disease. View Abstract
Local SAR management strategies to use two-channel RF shimming for fetal MRI at 3?T. View Abstract
Atypical fetal brain development in fetuses with non-syndromic isolated musculoskeletal birth defects (niMSBDs). View Abstract
Sleep Spindle Generation Before and After Epilepsy Surgery: A Source Imaging Study in Children with Drug-Resistant Epilepsy. View Abstract
Time-efficient, high-resolution 3T whole-brain relaxometry using 3D-QALAS with wave-CAIPI readouts. View Abstract
Analgesia after dorsal root ganglionic injection under CT-guidance in a patient with intractable phantom limb pain. View Abstract
Acute Diffusion-Weighted Imaging Signaling Severe Periventricular Leukomalacia in Preterm Infants: Case Report and Review of Literature. View Abstract
Negative versus withdrawn maternal behavior: Differential associations with infant gray and white matter during the first 2?years of life. View Abstract
SSL-QALAS: Self-Supervised Learning for rapid multiparameter estimation in quantitative MRI using 3D-QALAS. View Abstract
Association of cerebral metabolic rate following therapeutic hypothermia with 18-month neurodevelopmental outcomes after neonatal hypoxic ischemic encephalopathy. View Abstract
NeSVoR: Implicit Neural Representation for Slice-to-Volume Reconstruction in MRI. View Abstract
Morphological Features of Language Regions in Individuals with Tuberous Sclerosis Complex. View Abstract
Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study. View Abstract
Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study. View Abstract
Abnormal prenatal brain development in Chiari II malformation. View Abstract
Aluminum Thin Film Nanostructure Traces in Pediatric EEG Net for MRI and CT Artifact Reduction. View Abstract
Diffusion-Weighted Magnetic Resonance Imaging Demonstrates White Matter Alterations in Watershed Regions in Children With Moyamoya Without Stroke or Silent Infarct. View Abstract
Abnormal development of transient fetal zones in mild isolated fetal ventriculomegaly. View Abstract
Editorial: Imaging the developing connectome of perinatal brain. View Abstract
Effect of neonatal seizure burden and etiology on the long-term outcome: data from a randomized, controlled trial. View Abstract
A high-resolution pediatric female whole-body numerical model with comparison to a male model. View Abstract
Cross-Sectional Observational Study of Typical in utero Fetal Movements Using Machine Learning. View Abstract
Patterns of Neural Functional Connectivity in Infants at Familial Risk of Developmental Dyslexia. View Abstract
MRI Findings in Third-Trimester Opioid-Exposed Fetuses, With Focus on Brain Measurements: A Prospective Multicenter Case-Control Study. View Abstract
SVoRT: Iterative Transformer for Slice-to-Volume Registration in Fetal Brain MRI. View Abstract
Quantification of sulcal emergence timing and its variability in early fetal life: Hemispheric asymmetry and sex difference. View Abstract
Parallel transmission 2D RARE imaging at 7T with transmit field inhomogeneity mitigation and local SAR control. View Abstract
A Role for Data Science in Precision Nutrition and Early Brain Development. View Abstract
Increased Breastfeeding Proportion Is Associated with Improved Gross Motor Skills at 3-5 Years of Age: A Pilot Study. View Abstract
Age-related topographic map of magnetic resonance diffusion metrics in neonatal brains. View Abstract
Deep learning of birth-related infant clavicle fractures: a potential virtual consultant for fracture dating. View Abstract
Clinical experience with an in-NICU magnetic resonance imaging system. View Abstract
Magnetic resonance imaging metrics of oxygen extraction fraction: Contradictions or insight into pathophysiological mechanisms? View Abstract
Volumetric Parameterization of the Placenta to a Flattened Template. View Abstract
Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease. View Abstract
Improving Infant Hydrocephalus Outcomes in Uganda: A Longitudinal Prospective Study Protocol for Predicting Developmental Outcomes and Identifying Patients at Risk for Early Treatment Failure after ETV/CPC. View Abstract
Proceedings of the 13th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical. View Abstract
Assessment of Maternal Macular Pigment Optical Density (MPOD) as a Potential Marker for Dietary Carotenoid Intake during Lactation in Humans. View Abstract
Automated detection and reacquisition of motion-degraded images in fetal HASTE imaging at 3 T. View Abstract
Fetal Neuroimaging Updates. View Abstract
Edited magnetic resonance spectroscopy in the neonatal brain. View Abstract
Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging. View Abstract
Maternal Childhood Maltreatment Is Associated With Lower Infant Gray Matter Volume and Amygdala Volume During the First Two Years of Life. View Abstract
STRESS: Super-Resolution for Dynamic Fetal MRI using Self-Supervised Learning. View Abstract
Comparison of prospective and retrospective motion correction in 3D-encoded neuroanatomical MRI. View Abstract
Abnormal Right-Hemispheric Sulcal Patterns Correlate with Executive Function in Adolescents with Tetralogy of Fallot. View Abstract
Quantitative T1 and T2 mapping by magnetic resonance fingerprinting (MRF) of the placenta before and after maternal hyperoxia. View Abstract
Numerical simulation of the radiofrequency safety of 128-channel hd-EEG nets on a 29-month-old whole-body model in a 3 Tesla MRI. View Abstract
Functional Connectivity in Infancy and Toddlerhood Predicts Long-Term Language and Preliteracy Outcomes. View Abstract
Safety and imaging performance of two-channel RF shimming for fetal MRI at 3T. View Abstract
Neuroimaging of the Preterm Brain: Review and Recommendations. View Abstract
White matter in infancy is prospectively associated with language outcomes in kindergarten. View Abstract
Motion Analysis in Fetal MRI using Deep Pose Estimator. View Abstract
Learning-based automatic field-of-view positioning for fetal-brain MRI. View Abstract
Quantification of magnetic resonance spectroscopy data using a combined reference: Application in typically developing infants. View Abstract
Targeting human milk fortification to improve very preterm infant growth and brain development: study protocol for Nourish, a single-center randomized, controlled clinical trial. View Abstract
Abnormal Left-Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood. View Abstract
Intergenerational Transmission of Cortical Sulcal Patterns from Mothers to their Children. View Abstract
Rapid head-pose detection for automated slice prescription of fetal-brain MRI. View Abstract
Development, validation, and pilot MRI safety study of a high-resolution, open source, whole body pediatric numerical simulation model. View Abstract
De novo variants in MPP5 cause global developmental delay and behavioral changes. View Abstract
Voxelwise and Regional Brain Apparent Diffusion Coefficient Changes on MRI from Birth to 6 Years of Age. View Abstract
Fetal Cortical Plate Segmentation Using Fully Convolutional Networks With Multiple Plane Aggregation. View Abstract
Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease. View Abstract
Semi-Supervised Learning for Fetal Brain MRI Quality Assessment with ROI consistency. View Abstract
Enhanced detection of fetal pose in 3D MRI by Deep Reinforcement Learning with physical structure priors on anatomy. View Abstract
Brain Characteristics Noted Prior to and Following Cranial Orthotic Treatment. View Abstract
Placental MRI: Development of an MRI compatible ex vivo system for whole placenta dual perfusion. View Abstract
Identification of neuronal structures and pathways corresponding to clinical functioning in galactosemia. View Abstract
Detecting microstructural white matter abnormalities of frontal pathways in children with ADHD using advanced diffusion models. View Abstract
Fetal pose estimation from volumetric MRI using generative adversarial network. View Abstract
An Atypical Sulcal Pattern in Children with Disorders of the Corpus Callosum and Its Relation to Behavioral Outcomes. View Abstract
Spatiotemporal Differences in the Regional Cortical Plate and Subplate Volume Growth during Fetal Development. View Abstract
Temporal Patterns of Emergence and Spatial Distribution of Sulcal Pits During Fetal Life. View Abstract
BRAIN AGE ESTIMATION USING LSTM ON CHILDREN'S BRAIN MRI. View Abstract
Infant FreeSurfer: An automated segmentation and surface extraction pipeline for T1-weighted neuroimaging data of infants 0-2 years. View Abstract
Maternal Dietary Intake of Omega-3 Fatty Acids Correlates Positively with Regional Brain Volumes in 1-Month-Old Term Infants. View Abstract
Abnormal Left-Hemispheric Sulcal Patterns Correlate with Neurodevelopmental Outcomes in Subjects with Single Ventricular Congenital Heart Disease. View Abstract
Quantitative In vivo MRI Assessment of Structural Asymmetries and Sexual Dimorphism of Transient Fetal Compartments in the Human Brain. View Abstract
A phenotypically severe, biochemically "silent" case of HIBCH deficiency in a newborn diagnosed by rapid whole exome sequencing and enzymatic testing. View Abstract
Longitudinal structural connectomic and rich-club analysis in adolescent mTBI reveals persistent, distributed brain alterations acutely through to one year post-injury. View Abstract
Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy. View Abstract
Individual variation in simulated fetal SAR assessed in multiple body models. View Abstract
Placental Flattening via Volumetric Parameterization. View Abstract
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. View Abstract
Placental MRI: Developing Accurate Quantitative Measures of Oxygenation. View Abstract
Preliminary evaluation of dynamic glucose enhanced MRI of the human placenta during glucose tolerance test. View Abstract
Abnormalities in cerebral hemodynamics and changes with surgical intervention in neonates with congenital heart disease. View Abstract
Nutritive sucking abnormalities and brain microstructural abnormalities in infants with established brain injury: a pilot study. View Abstract
Maturation of Corticospinal Tracts in Children With Hemiplegic Cerebral Palsy Assessed by Diffusion Tensor Imaging and Transcranial Magnetic Stimulation. View Abstract
Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease. View Abstract
Altered White Matter Organization in the TUBB3 E410K Syndrome. View Abstract
Resting-State fMRI Networks in Children with Tuberous Sclerosis Complex. View Abstract
Network structural dependency in the human connectome across the life-span. View Abstract
Longitudinal Changes in Magnetic Resonance Spectroscopy in Pediatric Concussion: A Pilot Study. View Abstract
TRActs constrained by UnderLying INfant anatomy (TRACULInA): An automated probabilistic tractography tool with anatomical priors for use in the newborn brain. View Abstract
A novel missense mutation in TFAP2B associated with Char syndrome and central diabetes insipidus. View Abstract
Encephalopathy in neonates with subgaleal hemorrhage is a key predictor of outcome. View Abstract
Markerless high-frequency prospective motion correction for neuroanatomical MRI. View Abstract
GABA Transaminase Deficiency With Survival Into Adulthood. View Abstract
Automatic labeling of cortical sulci for the human fetal brain based on spatio-temporal information of gyrification. View Abstract
Developing a short-form of the Genetic Counselling Outcome Scale: The Genomics Outcome Scale. View Abstract
Field of View Normalization in Multi-Site Brain MRI. View Abstract
Surgical resection of ripple onset predicts outcome in pediatric epilepsy. View Abstract
Disorganized Patterns of Sulcal Position in Fetal Brains with Agenesis of Corpus Callosum. View Abstract
Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation. View Abstract
Exploring early human brain development with structural and physiological neuroimaging. View Abstract
Publisher Correction: Shedding light on the neonatal brain: probing cerebral hemodynamics by diffuse optical spectroscopic methods. View Abstract
Quantitative Apparent Diffusion Coefficient Mapping May Predict Seizure Onset in Children With Sturge-Weber Syndrome. View Abstract
MNE Scan: Software for real-time processing of electrophysiological data. View Abstract
Sulcal pits and patterns in developing human brains. View Abstract
Shedding light on the neonatal brain: probing cerebral hemodynamics by diffuse optical spectroscopic methods. View Abstract
Probabilistic tractography-based thalamic parcellation in healthy newborns and newborns with congenital heart disease. View Abstract
Can cerebellar and brainstem apparent diffusion coefficient (ADC) values predict neuromotor outcome in term neonates with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia? View Abstract
In Vivo Quantification of Placental Insufficiency by BOLD MRI: A Human Study. View Abstract
Frequency Diffeomorphisms for Efficient Image Registration. View Abstract
Reusable Client-Side JavaScript Modules for Immersive Web-Based Real-Time Collaborative Neuroimage Visualization. View Abstract
Using clinically acquired MRI to construct age-specific ADC atlases: Quantifying spatiotemporal ADC changes from birth to 6-year old. View Abstract
Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. View Abstract
Assessing the effects of subject motion on T2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators. View Abstract
Spatiotemporal alignment of in utero BOLD-MRI series. View Abstract
White Matter Alterations in Infants at Risk for Developmental Dyslexia. View Abstract
Current and Emerging Potential of Magnetoencephalography in the Detection and Localization of High-Frequency Oscillations in Epilepsy. View Abstract
The Potential for Advanced Magnetic Resonance Neuroimaging Techniques in Pediatric Stroke Research. View Abstract
High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults. View Abstract
Temporal Registration in In-Utero Volumetric MRI Time Series. View Abstract
Stroke in Acquired and Congenital Heart Disease Patients and Its Relationship to Hospital Mortality and Lasting Neurologic Deficits. View Abstract
Single-step quantitative susceptibility mapping with variational penalties. View Abstract
Real-time multi-channel monitoring of burst-suppression using neural network technology during pediatric status epilepticus treatment. View Abstract
Reduced cerebral blood flow and oxygen metabolism in extremely preterm neonates with low-grade germinal matrix- intraventricular hemorrhage. View Abstract
Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Performed in Acute Perinatal Stroke Reveals Hyperperfusion Associated With Ischemic Injury. View Abstract
Two unique TUBB3 mutations cause both CFEOM3 and malformations of cortical development. View Abstract
Sturge-Weber Syndrome: Brain Magnetic Resonance Imaging and Neuropathology Findings. View Abstract
Brain extraction in pediatric ADC maps, toward characterizing neuro-development in multi-platform and multi-institution clinical images. View Abstract
Failure to Identify the Left Arcuate Fasciculus at Diffusion Tractography Is a Specific Marker of Language Dysfunction in Pediatric Patients with Polymicrogyria. View Abstract
Comparison of accelerated 3-D spiral chemical shift imaging and single-voxel spectroscopy at 3T in the pediatric age group. View Abstract
Editorial on emerging neuroimaging tools for studying normal and abnormal human brain development. View Abstract
A FreeSurfer-compliant consistent manual segmentation of infant brains spanning the 0-2 year age range. View Abstract
RARE/turbo spin echo imaging with Simultaneous Multislice Wave-CAIPI. View Abstract
Retroclival collections associated with abusive head trauma in children. View Abstract
Fetal MRI: A Technical Update with Educational Aspirations. View Abstract
Cortical somatosensory reorganization in children with spastic cerebral palsy: a multimodal neuroimaging study. View Abstract
Multi-shell diffusion signal recovery from sparse measurements. View Abstract
Wave-CAIPI for highly accelerated 3D imaging. View Abstract
Diffuse correlation spectroscopy for measurement of cerebral blood flow: future prospects. View Abstract
Time efficiency and diagnostic agreement of 2-D versus 3-D ultrasound acquisition of the neonatal brain. View Abstract
Genetic influences and neuropathological sequelae of repetitive brain injury. Reply. View Abstract
Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report. View Abstract
Sex and the migraine brain. View Abstract
Development of cerebellar connectivity in human fetal brains revealed by high angular resolution diffusion tractography. View Abstract
Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. View Abstract
Maximum entropy estimation of glutamate and glutamine in MR spectroscopic imaging. View Abstract
Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia. View Abstract
Altered white matter connectivity and network organization in polymicrogyria revealed by individual gyral topology-based analysis. View Abstract
Clinical correlates in an experimental model of repetitive mild brain injury. View Abstract
Radial and tangential neuronal migration pathways in the human fetal brain: anatomically distinct patterns of diffusion MRI coherence. View Abstract
Whole genome sequencing identifies SCN2A mutation in monozygotic twins with Ohtahara syndrome and unique neuropathologic findings. View Abstract
Effects of sutures and fontanels on MEG and EEG source analysis in a realistic infant head model. View Abstract
Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. View Abstract
Non-invasive optical measurement of cerebral metabolism and hemodynamics in infants. View Abstract
A novel syndrome caused by the E410K amino acid substitution in the neuronal ß-tubulin isotype 3. View Abstract
Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates. View Abstract
Reliable identification of deep sulcal pits: the effects of scan session, scanner, and surface extraction tool. View Abstract
Diffusion propagator estimation from sparse measurements in a tractography framework. View Abstract
Detection of postmortem human cerebellar cortex and white matter pathways using high angular resolution diffusion tractography: a feasibility study. View Abstract
Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights. View Abstract
An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation. View Abstract
Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. View Abstract
A quantitative method for correlating observations of decreased apparent diffusion coefficient with elevated cerebral blood perfusion in newborns presenting cerebral ischemic insults. View Abstract
Diffusion tensor analysis of pediatric multiple sclerosis and clinically isolated syndromes. View Abstract
Regional infant brain development: an MRI-based morphometric analysis in 3 to 13 month olds. View Abstract
Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. View Abstract
Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines. View Abstract
Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant. View Abstract
Regional and hemispheric asymmetries of cerebral hemodynamic and oxygen metabolism in newborns. View Abstract
Altered fetal cerebral and cerebellar development in twin-twin transfusion syndrome. View Abstract
The confounding effect of systemic physiology on the hemodynamic response in newborns. View Abstract
Restricted diffusion in spinal cord infarction demonstrated by magnetic resonance line scan diffusion imaging. View Abstract
Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain. View Abstract
MR imaging of the term and preterm neonate with diffuse brain injury. View Abstract
Multimodal imaging of spike propagation: a technical case report. View Abstract
Emerging cerebral connectivity in the human fetal brain: an MR tractography study. View Abstract
Size-optimized 32-channel brain arrays for 3 T pediatric imaging. View Abstract
Quantitative comparison and analysis of sulcal patterns using sulcal graph matching: a twin study. View Abstract
Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. View Abstract
Diffusion-weighted imaging in neonates. View Abstract
The relationship between the presence of sulcal pits and intelligence in human brains. View Abstract
Acute liver failure and reversible leukoencephalopathy in a pediatric patient with homocystinuria. View Abstract
Fetal MR imaging evidence of prolonged apparent diffusion coefficient decrease in fetal death. View Abstract
In vivo proton beam range verification using spine MRI changes. View Abstract
Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life. View Abstract
MR connectomics: Principles and challenges. View Abstract
Tract-based analysis of callosal, projection, and association pathways in pediatric patients with multiple sclerosis: a preliminary study. View Abstract
Associations between the size of the amygdala in infancy and language abilities during the preschool years in normally developing children. View Abstract
New directions in clinical imaging of cortical dysplasias. View Abstract
Development of cerebral fiber pathways in cats revealed by diffusion spectrum imaging. View Abstract
Changes in white matter microstructure in patients with TLE and hippocampal sclerosis. View Abstract
Probabilistic atlas can improve reconstruction from optical imaging of the neonatal brain. View Abstract
Case records of the Massachusetts General Hospital. Case 23-2009. A 13-year-old boy with headache, nausea, seizures, and hypertension. View Abstract
Increased cerebral blood volume and oxygen consumption in neonatal brain injury. View Abstract
Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings. View Abstract
Predicting the location of entorhinal cortex from MRI. View Abstract
Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. View Abstract
Case records of the Massachusetts General Hospital. Case 7-2009. A pregnant woman with a large mass in the fetal oral cavity. View Abstract
Case records of the Massachusetts General Hospital. Case 1-2009. A 57-year-old man with progressive cognitive decline. View Abstract
Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia. View Abstract
Shape analysis with overcomplete spherical wavelets. View Abstract
Adriamycin injection into the medial cord of the brachial plexus: computed tomography-guided targeted pain therapy. View Abstract
Intrafamilial phenotypic variability in tuberous sclerosis complex. View Abstract
Magnetic resonance imaging evaluation of possible neonatal sinovenous thrombosis. View Abstract
Cortical Folding Development Study based on Over-Complete Spherical Wavelets. View Abstract
Magnetoencephalographic mapping of interictal spike propagation: a technical and clinical report. View Abstract
Assessment of infant brain development with frequency-domain near-infrared spectroscopy. View Abstract
Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation. View Abstract
Cortical surface shape analysis based on spherical wavelets. View Abstract
Significance of tissue anisotropy in optical tomography of the infant brain. View Abstract
Changes in cerebral cortex of children treated for medulloblastoma. View Abstract
Case records of the Massachusetts General Hospital. Case 35-2006. A newborn boy with hypotonia. View Abstract
Proton magnetic resonance spectroscopy and diffusion-weighted imaging in isolated sulfite oxidase deficiency. View Abstract
Case records of the Massachusetts General Hospital. Case 26-2006. A 19-year-old woman with difficulty walking. View Abstract
Our unborn children at risk? View Abstract
Detailed semiautomated MRI based morphometry of the neonatal brain: preliminary results. View Abstract
Cortical Surface Shape Analysis Based on Spherical Wavelet Transformation. View Abstract
Acute injury to the immature brain with hypoxia with or without hypoperfusion. View Abstract
The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. View Abstract
Diffusion-weighted MR imaging: pediatric clinical applications. View Abstract
Acute injury to the immature brain with hypoxia with or without hypoperfusion. View Abstract
Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure, disturbed gait, and altered mental status. View Abstract
3T phased array MRI improves the presurgical evaluation in focal epilepsies: a prospective study. View Abstract
Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature. View Abstract
Pediatric stroke: the child is not merely a small adult. View Abstract
Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. View Abstract
Can noninvasive imaging of biomarkers improve clinical grading of pediatric brain tumors? View Abstract
Dynamic statistical parametric mapping for analyzing the magnetoencephalographic epileptiform activity in patients with epilepsy. View Abstract
Imaging the developing epileptic brain. View Abstract
Parenchymal abnormalities associated with cerebral venous sinus thrombosis: assessment with diffusion-weighted MR imaging. View Abstract
Bilateral generalized polymicrogyria (BGP): a distinct syndrome of cortical malformation. View Abstract
Multimodal longitudinal imaging of focal status epilepticus. View Abstract
Evolution of water diffusion and anisotropy in hyperacute stroke: significant correlation between fractional anisotropy and T2. View Abstract
Structural MR imaging. View Abstract
Aids to telemetry in the presurgical evaluation of epilepsy patients: MRI, MEG and other non-invasive imaging techniques. View Abstract
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. View Abstract
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-2003. A newborn boy with petechiae and thrombocytopenia. View Abstract
Application of new MR techniques in pediatric patients. View Abstract
Diffusion-weighted imaging abnormalities in the splenium after seizures. View Abstract
A novel form of pontocerebellar hypoplasia maps to chromosome 7q11-21. View Abstract
Bilateral frontoparietal polymicrogyria: clinical and radiological features in 10 families with linkage to chromosome 16. View Abstract
Abnormal cortical development shown by 3D MRI in Prader-Willi syndrome. View Abstract
Diffusion magnetic resonance imaging of acute ischemic stroke. View Abstract
Perfusion magnetic resonance imaging of acute ischemic stroke. View Abstract
Practice parameter: neuroimaging of the neonate: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. View Abstract
Arterial ischemic stroke in childhood: the role of plasma-phase risk factors. View Abstract
Diffusion-weighted images in neonatal cerebral hypoxic-ischemic injury. View Abstract
An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21. View Abstract
Pediatric functional magnetic resonance imaging: progress and challenges. View Abstract
Diffusion MR imaging of acute ischemic stroke. View Abstract
Frequency and clinical context of decreased apparent diffusion coefficient reversal in the human brain. View Abstract
Diffusion-weighted MR imaging of the brain. View Abstract
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. View Abstract
MEG versus BOLD MR imaging: functional imaging, the next generation? View Abstract
Genetic and neuroradiological heterogeneity of double cortex syndrome. View Abstract
Diffusion MR imaging. Theory and applications. View Abstract
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