Mark P. Gorman, MD
Director, Pediatric Multiple Sclerosis & Related Disorders Program; Co-Director, Pediatric Neuroimmunology Center; Neurologist, Department of Neurology
Associate Professor of Neurology, Harvard Medical School
Image
Mark P. Gorman, MD
Director, Pediatric Multiple Sclerosis & Related Disorders Program; Co-Director, Pediatric Neuroimmunology Center; Neurologist, Department of Neurology
Associate Professor of Neurology, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
Duke University
1997
Durham
NC
Medical School
Harvard Medical School
2001
Boston
MA
Internship
Pediatrics
Boston Children's Hospital
2003
Boston
MA
Residency
Pediatrics
Boston Children's Hospital
2006
Boston
MA
Fellowship
Multiple Sclerosis and Neuro-immunology
Partners Adult and Pediatric MS Centers, Brigham and Women's Hospital and Massachusetts General Hospital
2008
Boston
MA
Certifications
American Board of Psychiatry and Neurology (Child and Adolescent Neurology)
Professional History
My practice specializes in pediatric neuroimmunology, which involves autoimmune conditions of the brain and spinal cord in children and adolescents. The most well-known condition within this field is multiple sclerosis (MS), but there are many other conditions, including opsoclonus myoclonus syndrome (OMS), autoimmune encephalitis, and central nervous system vasculitis, among others.
As a resident in both pediatrics and pediatric neurology at Boston Children's Hospital, I became fascinated clinically by demyelinating diseases (such as MS), a group of neuro-immune conditions in which the immune system damages the protective covering of the nerves called myelin. After finishing of my five-year residency, I completed a two-year fellowship in MS, becoming one of the first physicians nationwide with formal training in both pediatric neurology and multiple sclerosis.
Prior to my training, most children who presented with symptoms suggestive of demyelinating diseases would be referred out from Boston Children's Hospital to adult centers. I saw an unmet need to make great progress and help these children, and created Boston Children's first Pediatric Multiple Sclerosis Program.
With this base, I also started to see many children with other autoimmune disorders of brain and spinal cord. I was able to apply the knowledge and lessons I had learned in multiple sclerosis to these other conditions.
As an international expert in the care of children with these conditions, I have built my team from a small clinic into a large multidisciplinary program. My program includes nurses, nurse practitioners, psychologists, neuropsychologists, educational specialists and multiple consultants to address all of the medical, psychological, educational and social needs of the patients and families we see. In addition, I direct the hospital's inpatient neurology service and was in 2014 selected as the Department of Neurology's Teacher of the Year by the residents.
Approach to Care
I became very interested in working with children with disabilities during high school, when I volunteered at a summer camp for children with special needs.
The first summer that I worked at a week-long overnight camp, between my sophomore and junior years of high school, I worked with a child with Down syndrome. I became fascinated by how the brain works and by what wasn't working properly. And after a week I was exhausted: On an emotional, personal and social level I developed a deep respect for the abilities of children with special needs and the families who help care for them.
I started to read everything I could get my hands on about the brain. I went on to major in psychology with a focus in neuroscience at Duke University. During college I worked with Best Buddies, a group that matches students with young adults with intellectual disabilities, and greatly enjoyed these relationships.
From this personal interest, I trained in pediatric neurology. Through similarly moving patient-doctor relationships during my residency, I became fascinated by, and developed a specialization in, autoimmune diseases of the brain and spinal cord. I realized that often children and teens with these conditions were greatly in need of cohesive, coordinated care.
The first summer that I worked at a week-long overnight camp, between my sophomore and junior years of high school, I worked with a child with Down syndrome. I became fascinated by how the brain works and by what wasn't working properly. And after a week I was exhausted: On an emotional, personal and social level I developed a deep respect for the abilities of children with special needs and the families who help care for them.
I started to read everything I could get my hands on about the brain. I went on to major in psychology with a focus in neuroscience at Duke University. During college I worked with Best Buddies, a group that matches students with young adults with intellectual disabilities, and greatly enjoyed these relationships.
From this personal interest, I trained in pediatric neurology. Through similarly moving patient-doctor relationships during my residency, I became fascinated by, and developed a specialization in, autoimmune diseases of the brain and spinal cord. I realized that often children and teens with these conditions were greatly in need of cohesive, coordinated care.
Publications
Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis. View Abstract
Cognitive Function in People With Pediatric Multiple Sclerosis Over 2 Years. View Abstract
Evaluating Efficacy Outcomes in Pediatric Multiple Sclerosis Patients While Using Avonex or Plegridy via USNPMSC Registry. View Abstract
Genetic Landscape of Opsoclonus-Myoclonus-Ataxia Syndrome in Children. View Abstract
Epigenetic Aging in Pediatric-Onset Multiple Sclerosis. View Abstract
Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis. View Abstract
Childhood adversity in parents of patients with pediatric multiple sclerosis. View Abstract
Limited early IVIG for the treatment of pediatric myelin oligodendrocyte glycoprotein antibody-associated disease. View Abstract
Association Between Sun Exposure and Risk of Relapse in Pediatric-Onset Multiple Sclerosis. View Abstract
Study of the Association Between Menarche and Disease Course in Pediatric Multiple Sclerosis. View Abstract
Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease. View Abstract
Epidemiology and Impact of Social Hardships in Children With Multiple Sclerosis in the United States. View Abstract
Patient and family views on research priorities and design of clinical trials and research studies in pediatric multiple sclerosis. View Abstract
Early Adversity and Socioeconomic Factors in Pediatric Multiple Sclerosis: A Case-Control Study. View Abstract
Association of nutritional intake with clinical and imaging activity in pediatric multiple sclerosis. View Abstract
Inaugural Patient-Reported Registry of Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome: Presentation, Diagnosis, and Treatment of 194 Patients. View Abstract
Clinical and magnetic resonance imaging outcomes in pediatric-onset MS patients on fingolimod and ocrelizumab. View Abstract
Multiomic Analysis of Neuroinflammation and Occult Infection in Sudden Infant Death Syndrome. View Abstract
Gene-environment interactions: Epstein-Barr virus infection and risk of pediatric-onset multiple sclerosis. View Abstract
Gene-environment interactions and risk of pediatric-onset multiple sclerosis associated with time spent outdoors. View Abstract
Assessing Needs and Perceptions of Research Participation in Pediatric-Onset Multiple Sclerosis: A Multistakeholder Survey. View Abstract
Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset. View Abstract
Characteristics and predictors of disease course in children initially presenting with ADEM. View Abstract
Disease modifying treatment for pediatric onset multiple sclerosis: Ethical considerations and strategies to navigate parental refusal. View Abstract
MRI Features and Their Association With Outcomes in Children With Anti-NMDA Receptor Encephalitis. View Abstract
An International Pediatric-Onset Opsoclonus-Myoclonus Ataxia Syndrome Registry and Clinical Research Network: Development, Progress, and Vision. View Abstract
Demographic Features and Clinical Course of Patients With Pediatric-Onset Multiple Sclerosis on Newer Disease-Modifying Treatments. View Abstract
Characteristics of pediatric patients with multiple sclerosis and related disorders infected with SARS-CoV-2. View Abstract
Silent findings: Examination of asymptomatic demyelination in a pediatric US cohort. View Abstract
Therapeutic Response in Pediatric Neuromyelitis Optica Spectrum Disorder. View Abstract
Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System. View Abstract
MOG and AQP4 Antibodies among Children with Multiple Sclerosis and Controls. View Abstract
A new look at cognitive functioning in pediatric MS. View Abstract
Evaluation of white matter microstructure in pediatric onset multiple sclerosis with diffusion compartment imaging. View Abstract
An Evidence-Based Guideline Improves Outcomes for Patients With Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. View Abstract
Development of a multidisciplinary clinical approach for unexplained regression in Down syndrome. View Abstract
ZSCAN1 Autoantibodies Are Associated with Pediatric Paraneoplastic ROHHAD. View Abstract
Novel CAPN1 missense variants in complex hereditary spastic paraplegia with early-onset psychosis. View Abstract
Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective. View Abstract
A Single Stage Composite Cleft Septorhinoplasty for Correction of the Mature Unilateral Cleft Nose Deformity - The Gujrat Technique. View Abstract
Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution. View Abstract
Association Between Time Spent Outdoors and Risk of Multiple Sclerosis. View Abstract
Use and Safety of Immunotherapeutic Management of N-Methyl-d-Aspartate Receptor Antibody Encephalitis: A Meta-analysis. View Abstract
Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis. View Abstract
Increased Prevalence of Familial Autoimmune Disease in Children With Opsoclonus-Myoclonus Syndrome. View Abstract
Gut microbiome is associated with multiple sclerosis activity in children. View Abstract
Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA. View Abstract
Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis. View Abstract
International Consensus Recommendations for the Treatment of Pediatric NMDAR Antibody Encephalitis. View Abstract
RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes. View Abstract
Proposal to optimize evaluation and treatment of Febrile infection-related epilepsy syndrome (FIRES): A Report from FIRES workshop. View Abstract
Interleukin-6 Blockade With Tocilizumab in Anakinra-Refractory Febrile Infection-Related Epilepsy Syndrome (FIRES). View Abstract
Anakinra usage in febrile infection related epilepsy syndrome: an international cohort. View Abstract
Improved relapse recovery in paediatric compared to adult multiple sclerosis. View Abstract
IQ predictors in pediatric opsoclonus myoclonus syndrome: a large international cohort study. View Abstract
Pediatric Multiple Sclerosis Severity Score in a large US cohort. View Abstract
Adherence to study drug in a stroke prevention trial"?>. View Abstract
Rituximab in patients with pediatric multiple sclerosis and other demyelinating disorders of the CNS: Practical considerations. View Abstract
Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis. View Abstract
Posterior-onset Rasmussen's encephalitis with ipsilateral cerebellar atrophy and uveitis resistant to rituximab. View Abstract
Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation. View Abstract
Serial vessel wall MR imaging of pediatric tuberculous vasculitis. View Abstract
Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline. View Abstract
Pan-viral serology implicates enteroviruses in acute flaccid myelitis. View Abstract
SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. View Abstract
Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis. View Abstract
miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS. View Abstract
Vitamin D genes influence MS relapses in children. View Abstract
Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial. View Abstract
Pediatric CNS-isolated hemophagocytic lymphohistiocytosis. View Abstract
Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. View Abstract
Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. View Abstract
Clinical Subpopulations in a Sample of North American Children Diagnosed With Acute Flaccid Myelitis, 2012-2016. View Abstract
Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry. View Abstract
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. View Abstract
Scoring System to Optimize Pioglitazone Therapy After Stroke Based on Fracture Risk. View Abstract
Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children. View Abstract
Author Correction: Neuroimmune disorders of the central nervous system in children in the molecular era. View Abstract
Histopathologic Correlates of Familial Hemophagocytic Lymphohistiocytosis Isolated to the Central Nervous System. View Abstract
Health-related quality of life in children with inflammatory brain disease. View Abstract
Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. View Abstract
Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US. View Abstract
Several household chemical exposures are associated with pediatric-onset multiple sclerosis. View Abstract
Urban air quality and associations with pediatric multiple sclerosis. View Abstract
Heterogeneity in association of remote herpesvirus infections and pediatric MS. View Abstract
Case 27-2018: A 3-Year-Old Boy with Seizures. View Abstract
Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. View Abstract
Neuroimmune disorders of the central nervous system in children in the molecular era. View Abstract
Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial. View Abstract
Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis. View Abstract
Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update. View Abstract
Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update. View Abstract
Targeting Pioglitazone Hydrochloride Therapy After Stroke or Transient Ischemic Attack According to Pretreatment Risk for Stroke or Myocardial Infarction. View Abstract
Pioglitazone Prevents Stroke in Patients With a Recent Transient Ischemic Attack or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial (Insulin Resistance Intervention After Stroke). View Abstract
Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis. View Abstract
Genetic risk factors for pediatric-onset multiple sclerosis. View Abstract
Effects of pioglitazone on cognitive function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial. View Abstract
Smoking cessation and outcome after ischemic stroke or TIA. View Abstract
Examining the contributions of environmental quality to pediatric multiple sclerosis. View Abstract
Dietary factors and pediatric multiple sclerosis: A case-control study. View Abstract
Autoimmune encephalitis in children: clinical phenomenology, therapeutics, and emerging challenges. View Abstract
Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease. View Abstract
Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial. View Abstract
Response to Comment on Inzucchi et al. Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. Diabetes Care 2016;39:1684-1692. View Abstract
Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. View Abstract
Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial. View Abstract
Investigations in GABAA receptor antibody-associated encephalitis. View Abstract
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis. View Abstract
Distinct effects of obesity and puberty on risk and age at onset of pediatric MS. View Abstract
Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease. View Abstract
Characteristics of Children and Adolescents With Multiple Sclerosis. View Abstract
Dietary salt intake and time to relapse in paediatric multiple sclerosis. View Abstract
A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack. View Abstract
Voltage-gated potassium channel antibodies: Game over. View Abstract
Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. View Abstract
A case-control study of dietary salt intake in pediatric-onset multiple sclerosis. View Abstract
Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder. View Abstract
Using Radiological Data to Estimate Ischemic Stroke Severity. View Abstract
Autoimmune neurologic disorders in children. View Abstract
Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report. View Abstract
Pain and spinal cord imaging measures in children with demyelinating disease. View Abstract
Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis. View Abstract
Reply: To PMID 24907434. View Abstract
The Yield of Neuroimaging in Children Presenting to the Emergency Department With Acute Ataxia in the Post-Varicella Vaccine Era. View Abstract
Evaluation and treatment of autoimmune neurologic disorders in the pediatric intensive care unit. View Abstract
Impact of MS during the critical window of brain development. View Abstract
Protective environmental factors for neuromyelitis optica. View Abstract
The US Network of Pediatric Multiple Sclerosis Centers: Development, Progress, and Next Steps. View Abstract
Neuromyelitis optica in an adolescent after bone marrow transplantation. View Abstract
Pioglitazone for secondary prevention after ischemic stroke and transient ischemic attack: rationale and design of the Insulin Resistance Intervention after Stroke Trial. View Abstract
Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease. View Abstract
Visual outcomes in pediatric optic neuritis. View Abstract
Population-level evidence for an autoimmune etiology of epilepsy. View Abstract
Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study. View Abstract
Clinical application and evaluation of the Bien diagnostic criteria for Rasmussen encephalitis. View Abstract
Elevated relapse rates in pediatric compared to adult MS persist for at least 6 years. View Abstract
Increased Th17 response to myelin peptides in pediatric MS. View Abstract
Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis. View Abstract
Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network. View Abstract
Daclizumab use in patients with pediatric multiple sclerosis. View Abstract
Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis. View Abstract
Update on diagnosis, treatment, and prognosis in opsoclonus-myoclonus-ataxia syndrome. View Abstract
Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. View Abstract
Postvaricella acute transverse myelitis in a previously vaccinated child. View Abstract
Neonatal hypocalcemic seizures in siblings exposed to topiramate in utero. View Abstract
Locations